重組人血管內皮生長(cháng)因子-B, VEGF-B

貨號:

100-20B

品牌:

Peprotech

規格:

20μg

概述

Vascular Endothelial Growth Factor-B, VEGF-related factor, VRF

研究領(lǐng)域:

細胞生物學(xué)

詳述

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated, disulfide-linked homodimers, and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a cysteine knot-like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant Human VEGF-B is a 38.0 kDa, disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

氨基酸序列:

PVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR

來(lái)源:

E.coli

純度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF₁₆₅. The expected?ED₅₀?for this effect is 1.0-2.0 μg/ml.

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交叉反應:

Human

儲存與安全

儲存:

2℃~8℃

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Wolcavi Biotech致力于干細胞免疫治療、分子生物學(xué) 、免疫學(xué)、體外診斷等相關(guān)領(lǐng)域的實(shí)驗需求產(chǎn)品開(kāi)發(fā)和銷(xiāo)售。主要產(chǎn)品有抗原抗體|無(wú)血清培養基|細胞培養耗材并代理銷(xiāo)售Abcam、Invitrogen(Gibco)、Roche、Sigma、R&D、Meridian等二十多家國外知名品牌。

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重組人血管內皮生長(cháng)因子-B, VEGF-B