重組人β-神經(jīng)生長(cháng)因子, β-NGF

貨號:

450-01

品牌:

Peprotech

規格:

20μg

概述

NGF-β, beta-Nerve Growth Factor

研究領(lǐng)域:

腫瘤類(lèi)

細胞生物學(xué)

詳述

β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4.? These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.? β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.? β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival.? The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

氨基酸序列:

SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA

來(lái)源:

E.coli

純度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

determined by its ability to stimulate chick E9 DRG neurite outgrowth. The?ED₅₀?is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶units/mg.

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交叉反應:

Chicken, Hamster, Mouse, Rat, Human, Leech

儲存與安全

儲存:

2-8℃保存

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重組人β-神經(jīng)生長(cháng)因子, β-NGF